Italics and Quotation Marks

Q. I copyedit a technical journal, and I have a question about how CMOS would handle the term “Fortune 500.” Is “Fortune” (as the name of a publication) set in italics while “500” is not, or is “Fortune 500” treated as a standalone brand or fixed term akin to a trademark, where “Fortune” would be set roman? Thanks.

Q. Does a term following the word “called” need to be in italics or quotation marks—or neither? For example, “a series of bends called meanders.”

Q. In CMOS 8.117, why are Mars Global Surveyor and Mars Polar Lander not italicized? Aren’t they the names of specific spacecraft?

Q. If a word is used as a word but presented in all caps (or small caps), should it still be italicized or set in quotation marks (per CMOS 7.66)? For example: Fill in the squares with the letters that spell out BINGO. Or: Fill in the squares with the letters B, I, N, G, and O. In the latter case, the letters would be italicized. But putting the letters and the word in all caps and also italicizing them feels like overkill to me. It looks hideous. HELP!

Q. I am the managing editor of a business journal. Many of the authors I edit put the word “learn” in quotation marks when it applies to AI. For example, “The algorithm can be trained to ‘learn’ how people interact.” Does CMOS approve of this usage, or does it prefer to allow AI to learn like the rest of us, free from quotation marks?

Q. If direct internal dialogue is set in italics, should the comma before the dialogue tag be set in italics or roman? CMOS 6.2 is very fuzzy on this. For example: “I lied, he thought, but maybe she will forgive me.” Imagine that the dialogue itself is set in italics. Should the first comma be italicized?

Q. Are reverse italics [i.e., roman text in an otherwise italic context] used when a legal case includes names of newspapers that would normally be italicized on their own? Thank you!

Q. Hello, I’m wondering how to style the name of a television program that has been assimilated into the cultural lexicon so that references to it are not truly references to the show. In particular, an author said, “When I landed at the airport, it was as if I had entered the Twilight Zone.” (He makes many references to this.) I feel it should be capitalized but not italicized, but I can’t find anything to say one way or another. Can you help? Thanks!

Q. Would you italicize “x” in a phrase like “x number of dollars”? It seems like a variable, but I wasn’t sure if this casual use merited italics.

Q. Should sounds made by animals or objects be italicized when they aren’t part of dialogue (e.g., “quack,” “choo choo,” etc.)?