Italics and Quotation Marks

Q. If a word is used as a word but presented in all caps (or small caps), should it still be italicized or set in quotation marks (per CMOS 7.66)? For example: Fill in the squares with the letters that spell out BINGO. Or: Fill in the squares with the letters B, I, N, G, and O. In the latter case, the letters would be italicized. But putting the letters and the word in all caps and also italicizing them feels like overkill to me. It looks hideous. HELP!

Q. I am the managing editor of a business journal. Many of the authors I edit put the word “learn” in quotation marks when it applies to AI. For example, “The algorithm can be trained to ‘learn’ how people interact.” Does CMOS approve of this usage, or does it prefer to allow AI to learn like the rest of us, free from quotation marks?

Q. If direct internal dialogue is set in italics, should the comma before the dialogue tag be set in italics or roman? CMOS 6.2 is very fuzzy on this. For example: “I lied, he thought, but maybe she will forgive me.” Imagine that the dialogue itself is set in italics. Should the first comma be italicized?

Q. Are reverse italics [i.e., roman text in an otherwise italic context] used when a legal case includes names of newspapers that would normally be italicized on their own? Thank you!

Q. Hello, I’m wondering how to style the name of a television program that has been assimilated into the cultural lexicon so that references to it are not truly references to the show. In particular, an author said, “When I landed at the airport, it was as if I had entered the Twilight Zone.” (He makes many references to this.) I feel it should be capitalized but not italicized, but I can’t find anything to say one way or another. Can you help? Thanks!

Q. Would you italicize “x” in a phrase like “x number of dollars”? It seems like a variable, but I wasn’t sure if this casual use merited italics.

Q. Should sounds made by animals or objects be italicized when they aren’t part of dialogue (e.g., “quack,” “choo choo,” etc.)?

Q. Should the common name of a species from a non-English language be treated as a foreign word and italicized, or should it be left in roman type? I’m thinking of the bird known as a po‘ouli in Hawaii, which is elsewhere called the black-faced honeycreeper. Should po‘ouli be italicized?

Q. Robots are being named and even developing personalities, not just in fiction, but in the real world. Should their names be italicized—i.e., “I told Benjamin to wait at the coffee shop,” where Benjamin is a robot with artificial intelligence?

Q. Should the apostrophe in an italicized word in possessive plural form be italicized? Example: If I italicize the possessive form of the word pirates, would the apostrophe also be italicized?